Dr Brett McKinnon, Dr Akwasi Amaoko, Dr Keisuki Tanaka, Dr Sally Mortlock and Professor Grant Montgomery.

Our EQRS study is a collaboration between the Institute for Molecular Bioscience at UQ and the Royal Brisbane and Women’s Hospital to better understand the pathology of endometriosis, disease heterogeneity, clinical symptoms associated with subtypes and how these respond to various treatments.

EQRS is recruiting patients and collecting detailed symptom, life history, and clinical data. Tissue samples are collected to generate genomics information and develop in vitro models of individual cell types and co-cultures to assess the functional influence of genotypes on individual cellular function, gene transcription, alternative splicing, common and rare genetic mutations, proteomic and metabolomic profiles.

The results from our analyses will improve our understanding of endometriosis pathogenesis, the clinical symptoms associated with subtypes and how these respond to various treatments. Clinically relevant molecular signatures will be identified and applied to improve personalised treatments and identify novel treatments.